Wheel brightener scares the bejeezus out of me. If you go that route, wear eye, respiratory, and skin protection. I've been pretty well pleased with the Eagle 1 A2Z cleaner but it's not as strong as wheel brightener.
Once you get your wheels clean, you might want to do a sealant on them. Poli-Seal, Opti-Seal, or Klasse maybe. Should keep that brake dust from sticking so much in the future.