I have 3 year old twins, so I can relate to where you will be when your twins are born.
When my kids were born, we had an MDX, and it was fantastic for the most part. I'll tell you the two things about it that you may not think about. First, you will not be able to use the third row because of the car seats, so don't buy it for that. Also depending on how tall your wife is, it may become difficult to lift the car seats into the car as the kids get heavier. There were a few times where my wife (only 4'10") was standing on the step rail to put the car seat in and she slipped off and banged her leg on it. After the MDX lease was over, we needed to cut our payment WAY DOWN! So, we got the new Odyssey because I thought it would be easier for her and the kids to get into the car cause it's lower and has the automatic sliding doors, lots of rear cargo space, etc. Overall, it's great for the kids, they can climb in themselves easily, etc. My wife hates it, though. She feels like she is driving a bus! She would have been happier to give up some of the cargo space, and get into a smaller SUV or crossover. Also, whatever you get, make sure you have enough cargo room for the monster double stroller you will have! Good Luck and welcome to the club!