I always spray the wheel down with water, actually an electric power washer. Then I spray WB 4:1, and scrub with a wheel brush, and a small sponge for the face of the wheel. I don't use gloves and don't wear a haz mat suit either - I've been doing this for 6 years and have had had no issues. Now - I detail on the weekends, not everyday and I only use WB on the really crappy dirty neglected wheels so take this into consideration ok. Also, I spray a regular APC to neutralize the acid and clean up any left over crud, rinse like crazy and inspect.
BTW - just had my blood tested for the annual insurance forms at work, doc says I'll live to be an old man if the wife doesn't shoot me!