I have problems in my fingers (thanks to 6 years of ice hockey, I'm an old man at 18), so application by PC or Cyclo is the only way to go for me. I actually like applying waxes by cyclo, as I feel that the higher speed/pressure, combined with soft LC pads, burnishes the paint to a higher gloss.
Plus, the cyclo is so well balanced that I can reach out holding only the end of the handle, and it'll still work without destabilizing/falling over and scratching something. Big help on the roofs of fullsize crewcab trucks or RVs. Only thing to look out for is to make sure you use overlapping passes, so you cover the ever-so-slight gap between the pads.
Before I got my cyclo though, I always used my PC with every product but S100. S100 was so easy to apply/remove that I could just put the applicator in my palm and avoid the pain. I found that the PC made a huge diffirence with cleaner waxes, as using NXT or Collinite cleaner boat wax (forgot the #), along with a polishing pad seemed to get out some grime/defects that would not come out by hand.