This is one of those "well, it depends" situations where no one can really say. MOST people can polish as needed without having a problem. Plenty of people wetsand, use rotaries with strong products, etc. without hurting the clear. Then somebody cuts through the clear with just a PC and DACP (happened at the last St. Louis G-T-G).
Since you shouldn't get serious marring over and over again, it should be safe to polish your paint from time to time, using only the mildest product necessary to do the job.
Yeah, I realize that's NOT a cut and dried answer, but I don't think anybody can give you one.