GeeReg- I clean my tires with Griot's Rubber Cleaner, which is one *very* gentle product, so getting a little on my coated/LSPed wheels probably isn't a big deal. But no matter what I cleaned them with, I'd just try to use the least product necessary and, well...try to keep it off the wheels. I spray the product directly on the tire, but I'm pretty careful about it. Whether I'm scrubbing the tire with a "tire brush" (most tires) or a sponge (soft compound tires), I don't find it all that tough to keep the tire cleaning product off the wheel (maybe because I'm using so little tire cleaner, maybe it's just decades of experience).
It's the *rinsing* that can get tricky for me; I don't want the hose to blast the tire cleaning product everywhere. Sometimes I even resort to wipingit off with a sponge as thoroughly as I can before spraying the rinse water.
I'll be a [jerk] and suggest that you coat them

Hey, I don't coat the rest of the vehicle, only the wheels and some suspension/etc. bits. Cost effective *for me* because the wheels stay "done" for ages, saving me a whole lotta time.
On the vehicles whose wheels I seal, I just do it whenever it needs doing; the usual indicator is a change in the beading. Note that wipe-on-walk-away sealants (I use Garry Dean's Beyond Infinity Sealant) are almost as quick as using a QD (which I'd do after every wash anyhow).
The downside of using a LSP instead of a coating is that it's *VERY* tough to do a decent job on the inner barrels/back of the spokes without dismounting the wheel and even a
half-@$$ed job takes some doing. So while I do manage to keep those surfaces nice and clean, I'm not LSPing them as often/thoroughly as I'd really like. Using the OptiCoat makes this a moot point.